Gunslinger Girl (2003)
The girl has a mechanical body. However, she is still an adolescent child.
Overview
The Social Welfare Agency saves the lives of terminal patients using cybernetic implants. Then it teaches them to kill. After surviving the slaughter of her family, young Henrietta awakens to her new life at the Agency with a rebuilt body and no memory. Teamed with Jose, who is responsible for turning her into the perfect assassin, Henrietta’s been given a second chance—but at what cost?
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Set in modern Italy, story follows a group of traumatically-injured young girls taken from hospitals all over the country, who are then cybernetically enhanced, indoctrinated and trained to be assassins by a secret branch of the Public Corporation for Social Welfare, Section 2. Each girl is assigned to a male "handler" who oversees her training, deployments, and general conduct. Each handler is free to "condition" his cybernetic assassin to the extent he sees fit, which increases a girl’s lethality and loyalty at the expense of human individuality and lifespan.